Autoclave SST 20 - 110 l
The stirred tank reactor (STR) is the most widely used
bioreactor type. Applikon offers a unique product, the Bio Clave,
as an autoclavable stainless steel bioreactor for cell culture and
microbial culture applications.
The Bio Clave bioreactors are versatile, easy to use systems
that offer economical alternatives to steam-in-place bioreactors
and fermentors The Bio Clave range combines the advantages of both
the steam-in place bioreactor (robust design and pressurizable) and
the glass autoclavable bioreactors (flexibility and modularity).
The 316L stainless steel vessels are constructed according to the
latest standard on hygienic processing and cGMP. The interior
finish of the vessel is electropolished to Ra=0.4µm, while the
exterior is mirror polished. The high-grade surface finish secures
a better cleanability. The systems are built according to the
specific demands of a process using an extensive array of standard
components. Because of the modularity and flexibility, the user can
always adapt the systems to changed process demands. This results
in low initial investment and low running costs.
The Bio Clave bioreactor and fermentor are available in 20, 70
and 110 liter total volume. All systems are equipped with a top
driven stirrer who can be either a magnetically coupled or a
lipsealed stirrer system.
Bioreactors and fermentors
Applikon Bio Clave bioreactor and fermentor systems are designed
for maximum flexibility in setting up. The reactor headplate only
has entry ports and no welded pipes. This means that the systems
can be completely customized for the user's application. When the
application changes, the bioreactor set-up can easily be adapted to
the changed process demands. Headplates are made of 316L stainless
steel and all parts in the bioreactors have an electropolished
finish that ensures reliable cleanability of the vessel and
components. Vessels can be used up to 3.1 barg of
overpressure.
Lipseal or Magnetic Stirrers.
Specification
Ports: Head plate: 1x69.2mm,3x1.5"TC,4x27 & 3x16mm- Upper
Side Wall: 5x27mm - Lower Side Wall: 5xDN25
| Bio
Clave 20L |
Bio
Clave 70L |
Bio
Clave 110L |
| Bio
Clave reactor type |
20 liter |
70 liter |
110 liter |
| Inner
Diameter |
211 mm |
316 mm |
370 mm |
|
Inner Height (max.) |
631 mm |
957 mm |
1043 mm |
|
Liquid Height (working vol.) |
444 mm |
678 mm |
764 mm |
|
Ports Head Space section |
5 x 27 mm |
5 x 27 mm |
5 x 27 mm |
| Ports
Bottom section |
5 x DN 25 |
5 x DN 25 |
5 x DN 25 |
| Ports
Head Plate: |
|
1 x 69 mm |
1 x 69 mm |
1 x 69 mm |
|
3 x 16 mm |
3 x 16 mm |
3 x 16 mm |
|
4 x 27 mm |
4 x 27 mm |
4 x 27 mm |
|
3 x 1.5"TC |
3 x 1.5"TC |
3 x 1.5"TC |
|
Autoclave Space (HxD) |
1200 x 400 mm |
1900 x 600 mm |
1985 x 650 mm |
|
Overall height reactor |
715 mm |
1022 mm |
1110 mm |
| Total
Volume |
20 liter |
70 liter |
110 liter |
|
Working Volume |
15 liter |
50 liter |
80 liter |
| Min.
Working Volume |
4 liter |
13 liter |
21 liter |
| H/D
Total |
3 |
3 |
3 |
| H-D
Work Vol. |
2.2 |
2.2 |
2.2 |
| Design
Pressure Reactor |
4.1 bar |
4.1 bar |
4.1 bar |
| Test
Pressure Reactor |
4.8 bar |
4.8 bar |
4.8 bar |
| Design
Pressure Jacket |
6.2 bar |
6.2 bar |
6.2 bar |
| Test
Pressure Jacket |
11.2 bar |
11.2 bar |
11.2 bar |
|
Max. Temperature Reactor |
130 °C |
130 °C |
130 °C |
Vessel Volumes
|
Type |
Total
volume |
Working volume |
Minimum working volume |
H/D
ratio total volume |
H/D
ratio working volume |
|
20 |
21.9 |
14.6 |
4.4 |
3.0 |
2.0 |
|
70 |
74.2 |
49.5 |
13.7 |
3.0 |
2.0 |
|
110 |
110.0 |
73.3 |
20.3 |
2.8 |
1.9 |
Vessel Construction
- Interior Finish EP to Ra=0.8µm
- Exterior Mirror Polish
- Designed to ASME, Sec.VIII, Div.1
- Flush Mounted Longitudinal sight glass
- H:D Total Volume 3.1