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Mihail Tamarkin
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ez-Control

The ez-Control is an easy to use system for bioreactors and fermentors. The system accurately controls pH, Temperature, Dissolved Oxygen, Foam/Level and Agitation. The color touch screen interface guides the user through the operation. The adaptive control features allow the user to focus on the process while the controller keeps tight control on the important process parameters.

Ez control autoclavable

What makes this controller unique are its ease of use, its small footprint, its flexibility and its accurate control.

The system can control:

  • autoclavable bioreactors,
  • steam in place bioreactors,
  • Appliflex single use bioreactors
  • Millipore CellReady single use bioreactors
  • HyClone SUB bioreactors

Although the system has a very small footprint, the capabilities are beyond any other laboratory process control system.

Some of the ez-Control highlights are:

  • Simple operation through the color touch screen guides the operator and prevents errors
  • Adaptive PID control guarantees the most accurate control of your process parameters
  • OPC compliance eases integration in a computer network for process data handling
  • User definable control loop configuration offers unique flexibility in adding other sensors to your process
  • Define, store, copy and reload process configurations to reduce your experiment setup time
  • Local data storage and display up to 72 hours offers complete process overview on the lab bench
  • Synoptic, trending and bargraph displays supply all relevant process information in a glance
  • Multiple user s levels for secure access to the process
  • Can be used with classic and with fluorofor sensors (pH and oxygen) to match changing process demands
  • Can integrate viable biomass sensor for measurement and control to maximize process information
  • Due to the GAMP compliant development documentation the system can be used in validated processes

Features

Easy operation

The intuitive color touch screen display gives a clear overview of all process parameters and guides the operator.  Data is presented numerically, in line graphs and bar charts.

Security

The system has three user levels: Viewer, Operator and Engineer all have their own access rights.
Using the touch screen interface the user can alter the configuration of the system.  This enables the system to be used for different cultures without adding or removing hardware.  Just select the desired operation mode from the display and start the next culture.

Enhanced documentation and validation

The ez-Control was developed and documented in compliance with the GAMP 4 guidelines to enable users to fully validate the system for their process.
The system can be operated in a 21CFR part 11 compliant environment. The validation documentation package is available as an option.

Easy updates

Software updates are easy when functionality is developed.  Just connect the USB key with the software update to the USB port and system will automatically load the latest firmware.
Configuration storage and retrieval
Process specific configurations of the controller can be defined by the user. Multiple configurations can be stored and retrieved via a USB stick. This allows the user to easily reload configurations and copy these configurations to other ez-Control units without having to reprogram anything.

Ez synoptics

Advanced computer interface

The computer interface uses the well-proven Ethernet communication and complies with the OPC standard.  This means that you can plug it into a network and collect the data from anywhere in the network using one of Applikon's BioXpert software programs or any other industry standard SCADA programs.

Easy communication

The integrated web server allows access to the machine using standard internet browsers.  Via the browser the machine can be operated and actual process data can be viewed.  Your standard software can be used to view or control the system in the laboratory while you are at your desk.

Expandibility

The optional ADDA board offers an additional 8 analog inputs, 4 analog outputs, 8 digital inputs and 8 digital outputs.
This enormous amount of additional I/O power can be used to connect Biomass monitors, balances, gas analyzers, variable speed pumps, fixed speed pumps valves and other equipment to the ez-Control.
Virtually any bioprocess can be controlled through the standard 5 control loops and the control 14 outputs. With the ADDA card the total I/O count even reaches an impressive 21 inputs and 26 control outputs. This is in addition to the 2 integrated alarm outputs (process alarm and device alarm).
Other options include bottle racks for liquid additions and a set of lifting brackets for transport of the ez-Control.

Ez synoptics

Affordable

The ez-Control can be ordered as part of Applikon's BioBundle Family, therefore making this advanced system very affordable.

Adaptive control

What makes this controller smart is its capability to use adaptive control technology to automatically set the PID values.  This results in shorter development times and reduced time to market for your new products.
The adaptive process control can determine the optimal process conditions while the process is running.  This is particularly useful when viscosity of the culture increases during the process or when other physical properties of the process change.  The adaptive mode guarantees the best process control performance without the need to be a control specialist.